|
KMID : 0545120020120040679
|
|
Journal of Microbiology and Biotechnology
2002 Volume.12 No. 4 p.679 ~ p.682
|
|
|
Inhibition of Aflatoxin B_1 Biosynthesis by Piperlongumine Isolated from Piper longum L.
|
|
LEE, SUNG-EUN
MAHONEY, NOREEN E./CAMBELL, BRUCE C.
|
|
|
Abstract
|
|
|
|
The alkaloids, piperlongumine, piperine, pipemonaline, and piperoctadecalidine, isolated from Piper longum L., were found to inhibit the biosynthesis of aflatoxin B_1 (AFB_1) in Aspergillus flavus WRRC 3-90-42-12. Piperlongumine was the most active among the compounds tested, with a 96% inhibition of AFB_1 biosynthesis at 0.2% (w/v) supplement in a potato dextrose agar (PDA) medium. The three other piperidine alkaloids, piperine, pipernonaline, and piperoctadecalidine, also inhibited the biosynthesis of AFB_1. Of these three alkaloids, piperoctadecalidine exhibited a potent inhibitory activity with a 100% inhibition of AFB_1 production at 0.7% (w/v) supplement in a PDA medium. Therefore, piperlongumine and piperoctadecalidine could be used as antiaflatoxigenic agents in agricultural industries. To determine the antiaflatoxigenic mode of action of piperlongumine, further studies are needed.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|